Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 1648 0.0 0.999 0.154 0.267
biological_process el 1648 0.0 0.999 0.167 0.276
biological_process ka 1648 0.0 1.0 0.422 0.476
biological_process node2vec 1648 0.0 0.998 0.127 0.21
biological_process rf 1648 0.0 0.999 0.154 0.267
cellular_component ct 184 0.0 1.0 0.452 0.393
cellular_component el 184 0.0 1.0 0.498 0.487
cellular_component ka 184 0.0 1.0 0.634 0.479
cellular_component node2vec 184 0.0 0.985 0.25 0.295
cellular_component rf 184 0.0 1.0 0.498 0.487
disease ct 1456 0.0 0.993 0.05 0.143
disease el 1456 0.0 0.992 0.049 0.145
disease ka 1456 0.001 1.0 0.127 0.301
disease node2vec 1456 0.0 0.994 0.05 0.14
disease rf 1456 0.0 0.993 0.05 0.143
genetic_interaction_weighted ct 1668 0.0 1.0 0.328 0.272
genetic_interaction_weighted el 1668 0.0 1.0 0.329 0.274
genetic_interaction_weighted ka 1668 0.002 1.0 0.606 0.414
genetic_interaction_weighted rf 1668 0.0 1.0 0.326 0.273
molecular_function ct 476 0.0 1.0 0.376 0.343
molecular_function el 476 0.0 1.0 0.439 0.41
molecular_function ka 476 0.0 1.0 0.772 0.415
molecular_function node2vec 476 0.0 1.0 0.326 0.303
molecular_function rf 476 0.0 1.0 0.429 0.414
pathway ct 555 0.001 1.0 0.276 0.346
pathway el 555 0.001 1.0 0.236 0.338
pathway ka 555 0.001 1.0 0.47 0.484
pathway node2vec 555 0.0 0.994 0.274 0.303
pathway rf 555 0.001 1.0 0.233 0.334
phenotype ct 1357 0.0 1.0 0.157 0.288
phenotype el 1357 0.0 1.0 0.121 0.25
phenotype ka 1357 0.0 1.0 0.293 0.441
phenotype node2vec 1357 0.0 0.998 0.114 0.186
phenotype rf 1357 0.0 1.0 0.115 0.243
protein_interaction ct 1664 0.0 0.895 0.029 0.068
protein_interaction el 1664 0.0 0.896 0.093 0.134
protein_interaction ka 1664 0.0 1.0 0.062 0.187
protein_interaction rf 1664 0.0 0.895 0.029 0.068

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 0.904 0.139 0.192
integration_mean_by_presence el 1676 0.0 0.976 0.12 0.154
integration_mean_by_presence ka 1676 0.0 1.0 0.035 0.139
integration_mean_by_presence node2vec 1676 0.0 0.976 0.069 0.144
integration_mean_by_presence rf 1676 0.0 0.935 0.038 0.106
mean ct 1676 0.0 0.907 0.133 0.185
mean el 1676 0.0 0.936 0.109 0.142
mean ka 1676 0.0 1.0 0.033 0.14
mean node2vec 1676 0.0 0.959 0.052 0.13
mean rf 1676 0.0 0.909 0.035 0.098

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels